High Risk Cytogenetics is defined as one or more of t(4;14), t(14;16), or del 17p identified from FISH test results and is part of the staging criteria for plasma cell myeloma.

High Risk Cytogenetics is a prognostic factor required in AJCC 8th edition, Chapter 82 Plasma Cell Myeloma and Plasma Cell Disorders, for staging of plasma cell myeloma. It is a new data item for cases diagnosed 1/1/2018+.

0	High-risk cytogenetics not identified/not present
1	High-risk cytogenetics present
7	Test ordered, results not in chart
9	Not documented in medical record High Risk Cytogenetics not assessed or unknown if assessed

Each Site-Specific Data Item (SSDI) applies only to selected primary sites, histologies, and years of diagnosis. Depending on applicability and standard-setter requirements, SSDIs may be left blank.